靶向肿瘤因子c-MYC基因启动区G4-DNA的小分子药物设计及核磁共振研究进展
胡晓东,蓝文贤,王春喜,曹春阳*(
)
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Research Advance and NMR Studies of Anti-Cancer Small Molecules Targeting c-MYC G4-DNA
Xiao-dong HU,Wen-xian LAN,Chun-xi WANG,Chun-yang CAO*()
)
图8. (a) 三片层G-四链体在H2O(下)中及交换到D2O中1 h(上)后的亚氨基质子的一维氢谱；(b) RET G-四链体的拓扑结构[
Fig.8. (a) Imino proton region of one-dimensional 1H NMR spectra in H2O (down) and D2O (upper, exchanged from H2O sample 1 h later), respectively. (b) RET G4-DNA structure[
