靶向肿瘤因子c-MYC基因启动区G4-DNA的小分子药物设计及核磁共振研究进展
胡晓东,蓝文贤,王春喜,曹春阳*(
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Research Advance and NMR Studies of Anti-Cancer Small Molecules Targeting c-MYC G4-DNA
Xiao-dong HU,Wen-xian LAN,Chun-xi WANG,Chun-yang CAO*()
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图3. 已报道的c-MYC基因启动子的G4结构.(a) MYC基因的启动子结构和不同的相关元素；(b) MYC-1245、MYC-1234、MYC-2345、Pu22(4/14/23T) G4-DNA结构示意图.箭头指示5’到3’方向的DNA链；碱基G用圆圈表示，碱基A和T用正方形表示
Fig.3. Reported G4 structures in the c-MYC gene promoter. (a) The promoter structure of the MYC gene and different related elements; (b) Schematic demonstration of MYC-1245, MYC-1234, MYC-2345, and Pu22(4/14/23T) G4-DNA structures. The arrowheads indicate 5'-to-3' direction of DNA strands; guanines are shown by circles, and adenines and thymines are shown by boxes
