靶向肿瘤因子c-MYC基因启动区G4-DNA的小分子药物设计及核磁共振研究进展
胡晓东,蓝文贤,王春喜,曹春阳*(
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Research Advance and NMR Studies of Anti-Cancer Small Molecules Targeting c-MYC G4-DNA
Xiao-dong HU,Wen-xian LAN,Chun-xi WANG,Chun-yang CAO*()
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图2. G-四链体结构多样性.(a) G-四集体的四种链朝向；(b)三种主要的Loop连接方式；(c)单体分子内和双分子分子间G-四链体.红色箭头代表链从5’到3’朝向[
Fig.2. Structural diversity of G4 structures. (a) Four orientation of chains in G-tetrads; (b) Main three connection modes of loops; (c) Monomer or dimer G4 structure. The red arrow indicates the orientation from 5'-end to 3'-end[
