靶向肿瘤因子c-MYC基因启动区G4-DNA的小分子药物设计及核磁共振研究进展
胡晓东,蓝文贤,王春喜,曹春阳*(
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Research Advance and NMR Studies of Anti-Cancer Small Molecules Targeting c-MYC G4-DNA
Xiao-dong HU,Wen-xian LAN,Chun-xi WANG,Chun-yang CAO*()
)
图1. G-四链体结构组成.(a) G-四集体通过Hoogsteen氢键形成；(b) G-四链体结构中心被一价阳离子稳定
Fig.1. The structural composition of G-quadruplex. (a) G-tetrad formed by Hoogsteen hydrogen-bond; (b) The central structure of G-quadruplex is stabilized by monovalent cation
