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胶束型磁共振成像分子探针的设计与应用
肖龙1,2,朱筱磊1,韩叶清1,2,陈世桢1,2,*(),周欣1,2,*()
Design and Application of Micellar Magnetic Resonance Imaging Molecular Probe
Long XIAO1,2,Xiao-lei ZHU1,Ye-qing HAN1,2,Shi-zhen CHEN1,2,*(),Xin ZHOU1,2,*()

图5. 使用CEST监测PEG-b-PDPA聚合物的pH响应行为.(A)嵌段共聚物PEG114-b-PDPA116中的胶束-单体平衡对pH非常敏感. (B) (a) PEG-b-PDPA在pH 5.0和7.5时的CEST谱；(b)在pH 5.0到7.5范围内，不对称磁化转移率(MTRasym)与饱和频率偏移的关系图；(c) MTRasym与pH的关系；(d) pH 5.8时，MTRasym与PEG-b-PDPA共聚物浓度的关系[56]

Fig.5. The use of CEST for monitoring the pH-responsive behaviors of PEG-b-PDPA polymers. (A) The micelle-unimer equilibrium in the block copolymer, PEG114-b-PDPA116, is exquisitely sensitive to pH. (B) (a) Representative CEST spectra of PEG-b-PDPA at pH 5.0 and 7.5, respectively; (b) A plot of MTRasym versus the saturation frequency offset at the pH range between 5.0 and 7.5; (c) A plot of MTRasym versus pH; (d) A plot of MTRasym versus PEG-b-PDPA copolymer concentration at a fixed pH of 5.8[56]