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盐酸四环素中可交换氢和氢键的核磁共振波谱研究
谢金华1,王乐1,*(),刘盼1,苏稀琪1,MINGLi-June2,3
An NMR Spectroscopy Study on the Exchangeable Protons and Hydrogen Bonds in Tetracycline Hydrochloride
Jin-hua XIE1,Le WANG1,*(),Pan LIU1,Xi-qi SU1,Li-June MING2,3

图5. 和RNA（紫色，蛋白质银行代号：1HNW）及延伸因子Tu（青色, 蛋白质银行代号：2HDN）结合后的两个四环素结构重叠的立体图，左右两图为不同角度的立体视觉图[34, 35, 38]，其中绿色细线是潜在的氢键. RNA结合结构中的2(C)-CONH2键旋转180°以与Tu结合结构中的2(C)-CONH2键一致

Fig.5. Relaxed-eye stereo view of superimposed tetracycline structures from tetracycline-bound RNA (purple; PDB ID: 1HNW) and elongation factor Tu (cyan; PDB ID: 2HDN). The left and right pictures are for relaxed-eye stereo view[34, 35, 38]. The 2(C)-CONH2 bond in the RNA-bound structure was rotated by 180° to be consistent with that in the Tu-bound structure. The thin green lines are potential H-bonds with proton donors adjusted to proper positions in the H-bond donor/acceptor pairs