盐酸四环素中可交换氢和氢键的核磁共振波谱研究

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谢金华¹,王乐^1,*(

),刘盼¹,苏稀琪¹,MINGLi-June^2,³

An NMR Spectroscopy Study on the Exchangeable Protons and Hydrogen Bonds in Tetracycline Hydrochloride

Jin-hua XIE¹,Le WANG^1,*(

),Pan LIU¹,Xi-qi SU¹,Li-June MING^2,³

图2. 盐酸四环素及其衍生物的¹H NMR谱图.(a)盐酸甲烯土霉素；(b)盐酸土霉素；(c)盐酸四环素；(d)盐酸四环素（0.02 mmol）中加入5.5 mmol D₂O；(e)向盐酸四环素中加入一当量钴离子（CoCl₂·6H₂O）.(e)中的一些小信号是由质子与络合的顺磁Co²⁺耦合产生，(a)图中δ_H 1.06和3.44为商业残余乙醇；图中S表示溶剂峰，W表示水峰，*表示可交换氢

Fig.2. ¹H NMR spectra of tetracycline hydrochloride and its derivatives. (a) Metacycline hydrochloride; (b) Oxytetracycline hydrochloride; (c) Tetracycline hydrochloride; (d) Tetracycline hydrochloride (0.02 mmol) in DMSO-d₆ after addition of 5.5 mmol D₂O; (e) Tetracycline hydrochloride plus one equivalent cobalt ion (CoCl₂·6H₂O). Some minor signals in Fig. (e) are due to protons hyperfine-coupled with the bound paramagnetic Co²⁺; The two signals at δ_H 1.06 and 3.44 in Fig. (a) are ethanol residuals from the manufacturer. S represents the solvent peak, W represents the water peak, and * represents exchangeable hydrogen