德拉沙星葡甲胺波谱学数据解析

赵心怡,韩冬,罗红军,沈文斌,杨功俊

Spectroscopic Studies of Delafloxacin Meglumine

Xin-yi ZHAO,Dong HAN,Hong-jun LUO,Wen-bin SHEN,Gong-jun YANG

表2 德拉沙星葡甲胺样品的1H和13C NMR测定结果

Table 2 1H和13C NMR data of delafloxacin meglumine

Position δC(J/Hz) δH (J/Hz) 1H -1H COSY HMBC 2 148.3 8.36 (1H, s) / / 3 115.2 / / H-2 4 174.1 (d, 4JCF=1.4 Hz) / / H-2, H-5 5 110.2 (d, 2JCF =22.6 Hz) 7.76 (1H, d, 3JHF =14.0 Hz) / / 6 149.9 (d, 1JCF =246.8 Hz) / / H-5 7 141.6 (d, 2JCF =11.8 Hz) / / H-5, H-17, H-18 8 118.7 (d, 3JCF =6.7 Hz) / / H-2, H-5 9 135.7 / / H-2, H-5 10 104.9 (d, 3JCF =5.4 Hz) / / H-2, H-5 11 134.4 (dd, J=4.2/13.1 Hz) / / H-5, H-13, NH2 12 142.7 (dd, J=4.5/242.0 Hz) / / H-13 13 113.6 (t, 2JCF =22.3 Hz) 7.88 (1H, t, 3JHF=9.4 Hz) / / 14 144.7 (dd, J=5.2/253.1 Hz) / / H-13, NH2 15 145.6 (d, 2JCF =14.3 Hz) / / H-13 16 166.9 / / H-2 17 66.5 (d, 4JCF =4.5 Hz) 4.64 (2H, m) H-18 / 4.12 (2H, m) 18 61.2 (d, 5JCF =4.5 Hz) 4.46 (1H, quint, J=6.2 Hz) H-17 H-17 19 63.5 3.61 (1H, dd, J=3.3/10.9 Hz) H-20 H-20, H-21 3.42 (1H, dd, J=5.6/10.9 Hz) 20 71.3 3.52 (1H, m) H-19, H-21 H-19, H-21, H-22 21 70.7 3.47 (1H, dd, J=1.0/8.0 Hz) H-20, H-22 H-19, H-20, H-23 22 70.3 3.69 (1H, d, J=4.0 Hz) H-21, H-23 H-20, H-23, H-24 23 69.4 3.89 (1H, quint, J=3.5 Hz) H-22, H-24 H-21, H-22, H-24 24 52.0 2.94 (1H, dd, J=3.4/12.4 Hz) H-23 H-22, H-23, H-25 2.85 (1H, dd, J=7.9/12.4 Hz) 25 34.1 2.49 (3H, s) / H-24 NH2 / 6.64 (2H, s, br) / /