Chinese Journal of Magnetic Resonance ›› 2016, Vol. 33 ›› Issue (1): 133-141.doi: 10.11938/cjmr20160113

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Spectroscopy Study on Synthesis of Diisopropyl Coumarin-3-Phosphate by 31P NMR

LI Yuan-zhe1, QIU Li1, YIN Qiu-yue2, MAO Pu2, XIAO Yong-mei2, QU Ling-bo2, YUAN Jin-wei2   

  1. 1. Pharmaceutical College, Guangxi Medical University, Nanning 530021, China;
    2. School of Chemistry & Chemical Engineering, Henan University of Technology, Zhengzhou 450001, China
  • Received:2015-08-20 Revised:2016-01-22 Online:2016-03-05 Published:2016-03-05

Abstract:

Synthesis of diisopropyl coumarin-3-phosphate was tracked by 31P NMR, and the reaction mechanism was discussed using the materials of coumarin and diisopropyl H-phosphite and AgNO3 as the catalyst. The reaction conditions are optimized, and the regioselectivity of the reaction site is analyzed.

Key words: 31P NMR, diisopropyl coumarin-3-phosphate, synthesis

CLC Number: