Chinese Journal of Magnetic Resonance ›› 2015, Vol. 32 ›› Issue (4): 628-636.doi: 10.11938/cjmr20150408

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A 1H NMR-Based Metabonomic Study on the Serum of Haematitum-Treated Rats

WEI Ying1,2ZHANG Wen-jun1XUE Rong2LI Xiao-jing2*PEI Feng-kui2
  

  1. 1. Department of Chemistry, Hebei University of Technology, Tianjin 300130, China;
    2. Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
  • Received:2014-12-04 Revised:2015-10-23 Online:2015-12-05 Published:2015-12-05
  • About author:*Corresponding author: LI Xiao-jing, Tel: +86-431-85262219, E-mail: xjli@ciac.ac.cn.
  • Supported by:

    国家自然科学基金资助项目(20975097, 21305134)

Abstract:

Wistar rats were intragastrically administered with different doses (0, 2, 5 g/kg body weight) of haematitum. 1H NMR-based metabonomic techniques were used to analyze the metabolic profiles of the serum samples collected from the treated rats. Significant treatment-related changes were observed for the levels of β-hydroxybutyate, acetate, acetone, choline, glycerophosphorylcholine, glucose, lactate, low density lipoprotein, very low density lipoprotein and lipids. Such biochemical changes indicated that haematitum treatment at the dose of 2 or 5 g/kg body weight gave rise to reactive oxygen species (ROS) and caused peroxidation damage. It is concluded that haematitum treatment affects glucose, lipid and energy metabolism in rats.

Key words: nuclear magnetic resonance, metabonomics, principal component analysis, haematitum

CLC Number: