Noninvasive Visualization of in Vivo Drug Delivery with MRI

Abstract

Abstract:

Noninvasive visualization of in vivo delivery of liver specific non-ionic polymeric contrast agent in mice was studied with a 1.5 T clinical MRI scanner. Abdominal MR images were acquired immediately, 6, 12, 24, and 168 h (7 day) after injection of the contrast agents with a 3-inch diameter single-loop surface coil. Intensity non-uniformity correction and signal instability correction were performed before data analysis. The results showed that these corrections increased the data reliability and MRI was an effective method for noninvasive visualization of in vivo delivery of paramagnetically labeled polymer conjugates.

Key words: MRI, intensity non-uniformity correction, drug delivery, contrast agent

CLC Number:

R445.2

LI Jian-qi1, SHU Jie1, LUO Shu-fang2, YU Lei-2, DU Bing3, CHEN Qun1*. Noninvasive Visualization of in Vivo Drug Delivery with MRI[J]. Chinese Journal of Magnetic Resonance, 2007, 24(4): 420-425.

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