Chinese Journal of Magnetic Resonance ›› 2015, Vol. 32 ›› Issue (2): 354-362.doi: 10.11938/cjmr20150217

Previous Articles     Next Articles

Heterogeneous Structure and Miscibility of Phenylboronic Acid-Rich Chitosan Nanoparticles as Revealed by Advanced Solid-State NMR

WANG Fen-fen1,CHEN Tie-hong1,SUN Ping-chuan1,2,3*   

  1. 1. Key Laboratory of Functional Polymer Materials of Ministry of Education and College of Chemistry, Nankai University, Tianjin 300071;
    2. State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071;
    3. Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300071
  • Received:2015-02-11 Revised:2015-05-08 Online:2015-06-05 Published:2015-06-05
  • About author:WANG Fen-fen(1989-), female, born in Shandong, PhD., E-mail: wff@mail.nakai.edu.cn. *Corresponding author: SUN Ping-chuan, Tel: +86-22-23508171, E-mail: spclbh@nankai.edu.cn.
  • Supported by:

    The National Natural Science Foundation of China (20825416, 21374051).

Abstract:

By using advanced solid-state NMR techniques, the heterogeneous structure and inter-polymer miscibility of chitosan-poly (N-3-acrylamidophenyl-boronic acid) nanoparticles (CS-PAPBA NPs) were investigated. The 13C CPMAS experiments indicate the conformational change of chitosan when incorporated with phenyl boronic acid. Two-dimensional (2D) 13C-1H HETCOR experiments further demonstrate that a portion of chitosan is closely bound with
PAPBA in the interphase by means of boronic coordination interaction. 2D 1H-1H spin-exchange with spin-diffusion experiments demonstrate that the interfacial mixing of chitosan and PAPBA, and micro-phase separation is of the order of 15–20 nanometers.

Key words: solid-state NMR, heterogeneous structure, miscibility, nanoparticles, chitosan

CLC Number: