Visualize Diffusion Map of COPD Rat with Hyperpolarized Xenon MRI

doi:10.11938/cjmr20150209

Abstract

Abstract:

Hyperpolarized ³He or ¹²⁹Xe diffusion MRI has been demonstrated as a promising technique for the detection of microanatomical changes in chronic obstructive pulmonary disease (COPD). Compared with ³He, ¹²⁹Xe is more available for the potential clinical applications. However, the measurement of ¹²⁹Xe apparent diffusion coefficient (ADC) possesses more challenges due to the relevant low gyromagnetic ratio and spin polarization. In this present study, a single b value (b = 14 s/cm2) diffusion-weighted hyperpolarized ¹²⁹Xe MRI sequence was used to image a balloon phantom, healthy rats, and the COPD rats, respectively. All COPD rats were induced by second-hand smoke and lipopolysaccharide (LPS). The lung ¹²⁹Xe ADC maps were obtained on a 7 T MRI scanner. The mean lung parenchymal ¹²⁹Xe ADCs were 0.044 22±0.002 9 and 0.042 34±0.002 3 cm2/s (Δ = 0.8/1.2 ms) for the COPD rats, which showed significant increasements in comparison with healthy ones (0.037 7±0.002 3 and 0.036 7±0.001 3 cm2/s). Furthermore, the corresponding ADC histogram of the COPD rats exhibited a broader distribution as compared with the healthy ones. Our experiments demonstrated that the alveolar airspace
enlargement in the COPD rats are able to be quantitatively evaluated by hyperpolarized xenon diffusion-weighted MRI.

Key words: hyperpolarized xenon, MRI, lung, ADC, COPD

CLC Number:

O482.53

RUAN Wei-wei1,2，ZHONG Jian-ping1，HAN Ye-qing1，SUN Xian-ping1，YE Chao-hui1，ZHOU Xin1*. Visualize Diffusion Map of COPD Rat with Hyperpolarized Xenon MRI[J]. Chinese Journal of Magnetic Resonance, 2015, 32(2): 261-272.

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