A NMR STUDY OF ZOLMITRIPTAN

Abstract

Abstract:

A potent 5-HT_1B/1D receptor agonist, zolmitriptan, has been synthesized by the Fisher indole reaction. Its structure was elucidated by NMR using the selective long-range INEPT technique and the homo-/hetero-nuclear 2D NMR techniques.

Key words: NMR, zolmitriptan, selective long-range INEPT

CLC Number:

O641

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LIU Li-Jun, ZHONG Bai-Hua, MIAO Zhen-Chun. A NMR STUDY OF ZOLMITRIPTAN[J]. Chinese Journal of Magnetic Resonance, 2004, 21(1): 61-66.

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References

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[2] Robertson, Alan, Duncan, et al. Therapeutic heterocyclic compounds[P]. WO: 9 118 897, 1991-12-12.

[3] 梁晓天. 核磁共振-高分辨氢谱的解析和应用[M]. 北京：科学出版社，1976，284.

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