A Study on the Alteration of Spontaneous Brain Activity in Somatic Symptoms Disorder Combining Regional Homogeneity and Amplitude of Low-frequency Fluctuation

doi:10.11938/cjmr20212894

Abstract

Abstract:

Somatic symptom disorder (SSD) is a common medical disorder characterized by various biological, psychological, and social pathogenic factors. At present, little is known about the neural mechanism of SSD. This study evaluated the dysfunction in 45 patients with SSD and 43 controls by combining the amplitudes of low-frequency fluctuation (ALFF) and regional homogeneity (ReHo) methods with resting-state functional magnetic resonance imaging (fMRI). The patients with SSD exhibited significantly greater ReHo values in the right middle cingulate gyrus, and smaller ReHo values in the right precuneus, the left inferior temporal gyrus extending to the left middle temporal gyrus and the left parahippocampal gyrus, and the right pons compared with the controls. The SSD patients showed higher ALFF values in the middle cingulate gyrus extending to the left middle frontal gyrus, the right insula extending to the right inferior frontal gyrus, and left middle frontal gyrus extending to the left anterior cingulate cortex. These dysfunction areas are involved in self-relevant processes, emotional processing, and body perception, which are closely related to the pathogenesis of SSD.

Key words: somatic symptom disorder (SSD), regional homogeneity, amplitudes of low-frequency fluctuation (ALFF), functional magnetic resonance imaging (fMRI)

CLC Number:

O482.53

Yang-yang CUI,Huai-bin LIANG,Qian ZHU,Wei TANG,Ting-ting GAO,Jian-ren LIU,Xiao-xia DU. A Study on the Alteration of Spontaneous Brain Activity in Somatic Symptoms Disorder Combining Regional Homogeneity and Amplitude of Low-frequency Fluctuation[J]. Chinese Journal of Magnetic Resonance, 2022, 39(1): 64-71.

Figures/Tables 5

Table 1

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Table 2

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	SSD患者	健康对照	p值
男性/女性	20/25	19/24	0.97
年龄/岁	50.74±13.65	52.07±11.48	0.88
病程/年	2.03±0.85	/
PHQ-9	8.16±5.17	0~4
GAD-7	7.48±5.50	0~4
HAMA	9.31±4.62	0~8
HAMD	8.20±5.27	0~8
MMSE	27.39±2.35	27~30

	脑区	团块大小	T值	MNI坐标			p值^a
	脑区	团块大小	T值	x	y	z	p值^a
SSD患者 > 健康对照组	右侧扣带回中部	104	4.59	9	9	42	0.001
SSD患者 < 健康对照组	右侧楔前叶	83	5.04	18	?60	33	0.005
	左侧颞下回延伸至左侧颞中回及海马旁回	57	4.37	?33	0	?42	0.002
	右侧脑桥	52	4.24	21	?33	?36	0.003

	显著脑区	团块大小	T值	MNI坐标			p值^a
	显著脑区	团块大小	T值	x	y	z	p值^a
SSD患者 > 健康对照组	扣带回中部延伸到左侧额中回	63	4.93	?3	9	42	0.006
	右侧脑岛延伸至右侧额下回	52	4.78	36	15	9	0.016
	左侧额中回延伸至左侧前扣带回	44	4.74	?3	42	18	0.034