Effects of Tissue Coagulative Necrosis on Longitudinal Relaxation Time-Based Magnetic Resonance Thermometry

doi:10.11938/cjmr20182624

Abstract

Abstract: Real-time monitoring of tissue temperature is required during high intensity focused ultrasound (HIFU) tumor treatment to ensure safety and effectiveness. Magnetic resonance imaging (MRI) can be used to measure tissue temperature non-invasively during HIFU treatment. This paper examined the effects of coagulation necrosis-induced tissue phase transition on magnetic resonance thermometry (MRT) during HIFU tumor treatment. With a two-state rapid exchange model, the relationship between tissue longitudinal relaxation time (T₁) and temperature before and after HIFU radiation-induced coagulation necrosis/tissue phase transition were analyzed theoretically. Taking the effects of tissue phase transition into account, the experimental scheme and data processing procedures for MRT were optimized, and better temperature measurements were obtained. The work demonstrated the importance of considering the effects of tissue phase transition in real-time MRT during HIFU treatment.

Key words: high intensity focused ultrasound (HIFU), magnetic resonance thermometry (MRT), longitudinal relaxation time (T₁), two-state rapid exchange model

CLC Number:

HONG Sheng-xiu, HU Hong-bing, YANG Zeng-tao, ZHANG Tian-feng, HUANG Lei, WANG Hua. Effects of Tissue Coagulative Necrosis on Longitudinal Relaxation Time-Based Magnetic Resonance Thermometry[J]. Chinese Journal of Magnetic Resonance, 2018, 35(4): 440-446.

References

[1] 佚名. 国家癌症中心:2017最新中国肿瘤现状和趋势[OL].[2017-12-09]. http://www.medsci.cn/article/show_article.do?id=203a122910ce
[2] CHEN W Q, SUN K X, ZHENG R S, et al. Report of cancer incidence and mortality in different areas of China, 2014[J]. China Cancer, 2018, 27(1):1-14. 陈万青, 孙可欣, 郑荣寿, 等. 2014年中国分地区恶性肿瘤发病和死亡分析[J]. 中国肿瘤, 2018, 27(1):1-14.
[3] GAO T X, LV Z, DING H Y, et al. Chinese Journal of Medical Imaging, 2014, 22(7):547-550. 高天欣, 吕宙, 丁海艳, 等. 磁共振温度成像技术研究进展[J]. 中国医学影像学杂志, 2014, 22(7):547-550.
[4] 许永华. MRI引导、监测和评估HIFU治疗子宫肌瘤研究[D]. 重庆:重庆医科大学, 2014.
[5] LU Y, ZHENG X W, ZHONG K, et al. Research progresses in development of thermo-sensitive MRI contrast agent[J]. Chinese J Magn Reson, 2017(4):528-536. 路遥, 郑新威, 钟凯, 等. 温敏性磁共振成像造影剂的研究进展[J]. 波谱学杂志, 2017(4):528-536.
[6] GULTEKIN D H, GORE J C. Temperature dependence of nuclear magnetization and relaxation[J]. J Magn Reson, 2005, 172(1):133-141.
[7] TANG X Y, LIU Z W, PENG Y H, et al. Real-time non-invasive temperature measurement with MRI based on T₁[J]. Acta Electronica Sinica, 2009, 37(12):2770-2773. 唐晓英, 刘志文, 彭彧华, 等. 基于T₁的磁共振成像实时无创测温的研究[J]. 电子学报, 2009, 37(12):2770-2773.
[8] HYNYNEN K, POMEROY O, SMITH D N, et al. MR imaging-guided focused ultrasound surgery of fibroadenomas in the breast:a feasibility study[J]. Radiology, 2001, 219(1):176-185.
[9] FENNESSY F M, TEMPANY C M. MRI-guided focused ultrasound surgery of uterine leiomyomas[J]. Acad Radiol, 2005, 12(9):1158-1166.
[10] TEMPANY C M, STEWART E A, MCDANNOLD N, et al. MR imaging-guided focused ultrasound surgery of uterine leiomyomas:a feasibility study.[J]. Radiology, 2003, 226(3):897-905.
[11] FENNESSY F M, TEMPANY C M, MC DANNOLD N J, et al. Uterine leiomyomas:MR imaging-guided focused ultrasound surgery-results of different treatment protocols[J]. Radiology, 2007, 243(3):885-893.
[12] SCHLESINGER D, BENEDICT S, DIEDERICH C, et al. MR-guided focused ultrasound surgery, present and future[J]. Med Phys, 2013, 40(8):1-32.
[13] RIEKE V, BUTTS P K. Echo combination to reduce proton resonance frequency (PRF) thermometry errors from fat[J]. J Magn Reson Imaging, 2008, 27(3):673-677.
[14] WINTER L, OBERACKER E, PAUL K, et al. Magnetic resonance thermometry:Methodology, pitfalls and practical solutions[J]. Int J Hyperthermia, 2016, 32(1):63-75.
[15] GRISSOM W A, RIEKE V, HOLBROOK A B, et al. Hybrid referenceless and multibaseline subtraction MR thermometry for monitoring thermal therapies in moving organs[J]. Med Phys, 2010, 37(9):5014-5026.
[16] OLSRUD J, WIRESTAM R, BROCKSTEDT S, et al. MRI thermometry in phantoms by use of the proton resonance frequency shift method:application to interstitial laser thermotherapy[J]. Phys Med Biol, 1998, 43(9):2597-2613.
[17] GRAHAM S J, BRONSKILL M J, HENKELMAN R M. Time and temperature dependence of MR parameters during thermal coagulation of ex vivo rabbit muscle[J]. Magn Reson Med, 2010, 39(2):198-203.
[18] DIAKITE M, PAYNE A, TODD N, et al. Irreversible change in the T₁ temperature dependence with thermal dose using the PRF-T₁ technique[J]. Magn Reson Med, 2013, 69(4):1122-1130.
[19] DELANNOY J, CHEN C N, TURNER R, et al. Noninvasive temperature imaging using diffusion MRI[J]. Magn Reson Med, 1991, 19(2):333-339.
[20] HYNYNEN K, POMEROY O, SMITH D N, et al. MR imaging-guided focused ultrasound surgery of fibroadenomas in the breast:a feasibility study[J]. Radiology, 2001, 219(1):176-185.
[21] LIANG S N, SU H Y, ZHAO Y, et al. Evaluation of the safety and early therapeutic effect of magnetic resonance guided focused ultrasound surgery on uterine fibroids[J]. Biomedical Engineering and Clinical Medicine, 2012, 16(3):233-237. 梁松年, 苏洪英, 赵杨, 等. 磁共振引导下聚焦超声治疗子宫肌瘤安全性评价及近期疗效[J]. 生物医学工程与临床, 2012, 16(3):233-237.
[22] 于渌, 郝柏林. 相变和临界现象(I)[M]. 北京:科学出版社, 1984.
[23] PARKER D L, SMITH V, SHELDON P, et al. Temperature distribution measurements in two-dimensional NMR imaging[J]. Med Phys, 1983, 10(3):321-325.
[24] PELLER M, KURZE V, LOEFFLER R, et al. Hyperthermia induces T₁ relaxation and blood flow changes in tumors. A MRI thermometry study in vivo[J]. Magn Reson Imaging, 2003, 21(5):545-551.
[25] PELLER M, REINL H M, WEIGEL A, et al. T₁ relaxation time at 0.2 Tesla for monitoring regional hyperthermia:feasibility study in muscle and adipose tissue[J]. Magn Reson Med, 2002, 47(6):1194-1201.
[26] LEWA C J, MAJEWSKA Z. Temperature relationships of proton spin-lattice relaxation time T₁ in biological tissues[J]. Bull Cancer, 1980, 67(5):525-530.
[27] 俎栋林, 高家红. 核磁共振成像:物理原理和方法[M]. 北京:北京大学出版社, 2014.
[28] BOTTOMLEY P A, FOSTER T H, ARGERSINGER R E, et al. A review of normal tissue hydrogen NMR relaxation times and relaxation mechanisms from l-100MHz:Dependence on tissue type, NMR frequency, temperature, species, excision and age[J]. Med Phys, 1984, 11(4):425-448.