Chinese Journal of Magnetic Resonance

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An NMR Study on Inclusion Complex of β-Cyclodextrin with 3S-tetrahydro-isoquinoline-3-carboxylic Acid

ZHENG Mei-qing1, ZHAO Shu-rui1, WU Ying-ting1, WANG Yao-nan1, WANG Yu-ji2*   

  1. 1. Center of Medical Experiment and Analysis, Capital Medical University, Beijing 100069, China;
    2. School of Chemical Biology and Pharmaceutical Sciences, Capital Medical University, Beijing 100069, China
  • Received:2012-02-23 Revised:2012-05-28 Online:2013-06-05 Published:2013-06-05
  • About author:*Corresponding author: Wang Yu-ji,Tel: 010-83911530,E-mail: ccmuwyj@126.com.
  • Supported by:

    首都医科大学校自然基金资助项目(2013ZR17).

Abstract:

The interaction between β-cyclodextrin (β-CD) with 3S-tetrahydro-isoquinoline-3-carboxylic acid (THIQA) was studied by high-resolution liquid-state NMR spectroscopy. The spectra of β-CD and the β-CD/THIQA inclusion complex were compared. The results of 2D ROESY experiments further revealed the interactions between H5/H6 of β-CD and THIQA.

Key words: NMR,  β-cyclodextrin,  , 3S-tetrahydro-isoquinoline-3-carboxylic acid, inclusion complex

CLC Number: