Solid-State NMR Studies on Amyloid Fibrils: Recent Progresses

Abstract

Abstract:

Amyloid fibrils are fibriform aggregates of amyloid proteins, which are implicated in many protein deposition diseases. Knowing the structures of amyloid fibrils will shed light on the molecular mechanism of fibrillation, facilitating the prevention and therapy of related diseases. Solid-state NMR is the most prospective technique for elucidating the structures of amyloid fibrils, since they are insoluble and non-crystalline such that they are difficult to be studied by liquid-state NMR and X-ray diffraction approaches. In this paper, recent progresses on using solid-state NMR methods to elucidate structural information of proteins, especially amyloid fibrils, are reviewed.

Key words: solid-state NMR, amyloid fibril, three-dimensional structure, magic angle spinning, protein, secondary structure

CLC Number:

O482.53

ZHANG Zheng-feng1,2, YANG Jun1*. Solid-State NMR Studies on Amyloid Fibrils: Recent Progresses[J]. Chinese Journal of Magnetic Resonance.

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