Chinese Journal of Magnetic Resonance ›› 2005, Vol. 22 ›› Issue (2): 141-147.

• Articles • Previous Articles     Next Articles

Interactions between α-Cyclodextrin and Small Organic Molecules Like Salicylic Acid Studied by NMR Diffusion Measurements

  

  1. Analytical Center and the Key Laboratory of Education Ministry for Optics and Magnetic Resonance Spectroscopy,East China Normal University,Shanghai 200062,China
  • Received:2004-10-14 Revised:2004-11-16 Online:2005-06-05 Published:2005-06-05
  • Supported by:

    上海市纳米专项基金(0252NM011)和教育部优秀青年教师教学与科研奖励基金资助.

Abstract:

The interactions between α-cyclodextrin and four ligands (salicylic acid, salicylate, phenol and benzoate) was studied by NMR diffusion measurements. The diffusion coefficients of the ligands in the solution, which reflects the affinity of association between α-cyclodextrin and them, were found to decrease as the concentration of α-cyclodextrin increased. Together with 2D-ROESY experiments, it was demonstrated that in forming inclusion complex, the hydrophobic interaction is predominant among various possible interactions between α-cyclodextrin and the ligands.

Key words: NMR, gradient field, ROESY, self-diffusion coefficient, complex

CLC Number: