Design and Evaluation of a Caloric Stimulation Device for fMRI Studies

doi:10.11938/cjmr20160105

Abstract

Abstract:

In this study, we designed and verified a computer-controlled caloric stimulation device for delivering caloric stimulation in functional magnetic resonance imaging (fMRI) environment. The stimulation device consists of a caloric stimulation generation unit and a control unit. The control system unit includes a microcontroller module which can process stimulation command written in LabVIEW, and then transfer the stimulation sequence to a digital PID temperature control module to achieve exact caloric stimulation via a small peltier-pod. The performance of the device was evaluated with caloric stimulation fMRI experiments, and the results from 5 test subjects demonstrated the reliability of the device.

Key words: fMRI, stimulation device, LabVIEW, caloric stimulation

CLC Number:

DONG Tao, LIANG Si, WANG Hui, YANG Xiao-dong. Design and Evaluation of a Caloric Stimulation Device for fMRI Studies[J]. Chinese Journal of Magnetic Resonance, 2016, 33(1): 54-65.

References

[1] Ogawa S, Lee T M, Kay A R, et al. Brain magnetic resonance imaging with contrast dependent on blood oxygenation[J]. P Nat Acad Sci USA, 1990, 87(24): 9 868－9 872.

[2] Wang Min-rui(王敏锐). fMRI Research on Brain Mechanisms of Stroke and Normal Movement of the Hands and Feet(脑卒中者及正常人手足运动脑机制的fMRI研究)[D]. Hefei(合肥): Medical University of Anhui(安徽医科大学), 2013.

[3] Zhou Gao-feng(周高峰), Wang Xiao-yi(王小宜), Huang Man-ping(黄满平), et al. BOLD-fMRI in sensory area and motor hand functional area with brain tumor in the central area(中央区良恶性脑肿瘤手运动及感觉功能区的BOLD-fMRI表现)[J]. J Cent South Univ (Med Sci) [中南大学学报(医学版)], 2008, 7: 576－581.

[4] Zhou Yang(周扬). fMRI Studies on Face and Object Recognition in Human Anisometropic Amblyopia and Chinese Characters Recognition in Health People(屈光参差性弱视面孔及物体形觉认知和正常人群对汉字认知大脑皮层功能活动特征的fMRI研究)[D]. Chongqing(重庆): Third Military Medical University(第三军医大学), 2007.

[5] Zhang Shu-ying(张鉥缨). BOLD-Functional Magnetic Resonance Imaging on Demonstrating the Brain Domains of Language、Memory of Patients With Epilepsy and Influencing of Antiepileptic Drugs on These Cerebral Areas(BOLD功能磁共振成像在癫痫患者语言、记忆功能区及其抗癫痫药物影响作用的研究)[D]. Chengdu(成都): Sichuan University(四川大学), 2007.

[6] Xiang Ai-zhai(项爱斋), Zhang Yun-ting(张云亭), Zhang Quan(张权), et al. The activation of human affective system during passive music listening: A preliminary fMRI study(音乐刺激激活人脑情感系统的fMRI研究)[J]. Chinese Journal of Clinical Psychology(中国临床心理学杂志), 2006, 14(2): 215－217.

[7] Kwong K K, Belliveau J W, Chesler D A, et al. Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation[J]. P Natl Acad Sci USA, 1992, 89(12): 5 675－5 679..

[8] Ogawa S, Tank D W, Menon R, et al. Intrinsic signal changes accompanying sensory stimulation: Functional brain mapping with magnetic resonance imaging[J]. P Natl Acad Sci USA, 1992, 89(13): 5 951－5 955.

[9] Buckner R L, Bandettini P A, O'Craven K M, et al. Detection of cortical activation during averaged single trials of a cognitive task using functional magnetic resonance imaging[J]. P Natl Acad Sci USA, 1996, 93(25): 14 878－14 883.

[10] Hsieh Chang-wei(谢长倭), Wu Jih-huah(吴季华), Hsieh Chao-hsien(谢昭贤), et al. The preliminary fMRI investigation of 10 Hz modulation laser acupuncture induced cerebral cortical activation in human(以功能磁共振造影初探10 Hz调制激光针灸刺激所引发人类大脑皮质的活化现象)[J]. Chinese J Magn Reson(波谱学杂志), 2010, 27(3): 369－378.

[11] Wang Xiao-guan(王骁冠), Zhu Zhen-wei(祝祯伟), Yang Xiao-dong(杨晓冬), et al. Advances in automatic stimulation devices for functional magnetic resonance imaging(功能磁共振成像自动刺激装置研究进展)[J]. China Medical Devices (中国医疗设备), 2013, 28(1): 1－8.

[12] Wang Xiao-guan(王骁冠), Wang Hui(王慧), Yang Xiao-dong(杨晓冬), et al. Design and evaluation of an olfactometer for fMRI studies(一种用于fMRI的嗅觉刺激装置设计与验证)[J]. Chinese J Magn Reson(波谱学杂志), 2014, 31(4): 477－487.

[13] Rolls E T, Grabenhorst F, Parris B A. Warm pleasant feelings in the brain[J]. Neuroimage, 2008, 41(4): 1 504－1 513.

[14] Becerra L R, Breiter H C, Stojanovic M, et al. Human brain activation under controlled thermal stimulation and habituation to noxious heat: An fMRI study[J]. Magn Reson Med, 1999, 41(5): 1 044－1 057.

[15] Chen L M, Dillenburger B C, Wang F, et al. Differential fMRI activation to noxious heat and tactile stimuli in parasylvian areas of new world monkeys[J]. Pain, 2012, 153(1): 158－169.

[16] Elliott C, Vijayakumar V, Zink W, et al. National instruments LabVIEW: A programming environment for laboratory automation and measurement[J]. JALA, 2007, 12(1): 17－24.

[17] Davis K D, Kwan C L, Crawley A P, et al. Functional MRI study of thalamic and cortical activations evoked by cutaneous heat, cold, and tactile stimuli[J]. J Neurophysiol, 1998, 80(3): 1 533－1 546.

[18] Brooks J C W, Zambreanu L, Godinez A, et al. Somatotopic organisation of the human insula to painful heat studied with high resolution functional imaging[J]. Neuroimage, 2005, 27(1): 201－209.

[19] Craig A D, Reiman E M, Evans A, et al. Functional imaging of an illusion of pain[J]. Nature, 1996, 384(6 606): 258－260.

[20] Craig A D, Chen K, Bandy D, et al. Thermosensory activation of insular cortex[J]. Nat Neurosci, 2000, 3(2): 184－190.

[21] Tracey I, Becerra L, Chang I, et al. Noxious hot and cold stimulation produce common patterns of brain activation in humans: A functional magnetic resonance imaging study[J]. Neurosci Lett, 2000, 288(2): 159－162.

[22] Casey K L, Minoshima S, Morrow T J, et al. Comparison of human cerebral activation pattern during cutaneous warmth, heat pain, and deep cold pain[J]. J Neurophysiol, 1996, 76(1): 571－581.

[23] Craig A D, Chen K, Bandy D, et al. Thermosensory activation of insular cortex[J]. Nat Neurosci, 2000, 3(2): 184－190.

[24] Fasold O, von Brevern M, Kuhberg M, et al. Human vestibular cortex as identified with caloric stimulation in functional magnetic resonance imaging[J]. Neuroimage, 2002, 17(3): 1 384－1 393.

[25] [OL] http://www.ruf.rice.edu/~lngbrain/cglidden/parietal.html.