Three-Dimensional Multi-Echo Quantitative Susceptibility Mapping with Flow Compensation

doi:10.11938/cjmr20150306

Abstract

Abstract:

Venous blood oxygen saturation, cerebral microbleeds, iron deposition and tissue calcification can be measured by quantitative susceptibility mapping (QSM) via deconvolving the magnetic resonance (MR) phase signal. However, accurate estimation of phase signal and magnitude image in QSM may be affected by flow-induced errors in the presence of field gradient, which would ultimately lead to errors in the quantitative susceptibility map reconstructed. The aim of this study is to develop a method for correcting the flow-induced errors in phase signal and magnitude image in QSM. Flow-compensated data acquisition was achieved using a three-dimensional full flow compensated multi-echo gradient echo sequence. Phantom and in vivo experiments were carried out to validate the method proposed. The results of these experiments demonstrated that flow compensation can reduce errors in the phase signal and magnitude images. Improved quantitative susceptibility map of the superior sagittal sinus vein in human brain could be obtained with the proposed method.

Key words: MRI, quantitative susceptibility mapping, flow compensation, 3D multi-echo GRE, flow artifacts

CLC Number:

O482.53

WENG Peng-fei1，DONG Fang1，WANG Qian-feng1，PEI Meng-chao1，LIU Tian2，WANG Yi1,3,4，LI Jian-qi1*. Three-Dimensional Multi-Echo Quantitative Susceptibility Mapping with Flow Compensation[J]. Chinese Journal of Magnetic Resonance, 2015, 32(3): 450-461.

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