Synthesis of 1-Hydroxyethylidene-1,1-Diphosphonic Acid (HEDP) Monitored by 31P NMR

doi:10.11938/cjmr20150113

Chinese Journal of Magnetic Resonance ›› 2015, Vol. 32 ›› Issue (1): 116-122.doi: 10.11938/cjmr20150113

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Synthesis of 1-Hydroxyethylidene-1,1-Diphosphonic Acid (HEDP) Monitored by ³¹P NMR

DU Cheng-tang*，ZHUANG Dong-qing，SHI Bo

Laboratory of Functional Chemicals, Feixiang Institute of New Materials, Suzhou 215026, China

Received:2014-05-19 Revised:2015-01-11 Online:2015-03-05 Published:2015-03-05
About author:*Corresponding author：DU Cheng-tang, Tel: +86-13776190197, E-mail: duchengtang200@163.com.

In this paper, we report the use of ³¹P NMR to monitor the synthesis process of 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP). ³¹P NMR was used to detect signals from the residues of key intermediates phosphorous acid and 3. The synthesis process was optimized based on the ³¹P NMR results. Impurity such as PCl₃ were analyzed.

Key words: ³¹P NMR, HEDP, process optimization

CLC Number:

O482.53

Cite this article

DU Cheng-tang*，ZHUANG Dong-qing，SHI Bo. Synthesis of 1-Hydroxyethylidene-1,1-Diphosphonic Acid (HEDP) Monitored by ³¹P NMR[J]. Chinese Journal of Magnetic Resonance, 2015, 32(1): 116-122.

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Synthesis of 1-Hydroxyethylidene-1,1-Diphosphonic Acid (HEDP) Monitored by ³¹P NMR

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