风轮菜属三萜皂苷与黄酮研究进展及波谱特征

波谱学杂志

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风轮菜属三萜皂苷与黄酮研究进展及波谱特征

王圣男1，余世春1,3*，许旭东2，佘守军3，范石虎3

1. 安徽中医学院，安徽合肥 230031； 
2. 中国医学科学院北京协和医学院药用植物研究所，北京 100193； 
3. 安徽科创药物研究所有限责任公司，安徽合肥 230088

收稿日期:2012-08-30 修回日期:2013-04-08 出版日期:2013-09-05 发布日期:2013-09-05
作者简介:王圣男（1987-）, 女，安徽人，硕士研究生，研究方向为中药有效成分与质量控制研究，电话：13855139625, E-mail：shengnan.0212@163.com. *通讯联系人：余世春，电话：13956081725, E-mail：shichunyu@hotmail.com.
基金资助:
国家自然科学基金资助项目（81173511）；“十一五”“重大新药创制”国家科技重大专项——综合性新药研究开发技术大平台资助（2009ZX093012003）.

Triterpenoid Saponins and Flavonoids from Clinopodium Linn.: Chemical Component Analyses and NMR Spectral Features

WANG Sheng-nan1, YU Shi-chun1,3*, XU Xu-dong2, SHE Shou-jun3, FAN Shi-hu3

1. Anhui University of Traditional Chinese Medicine, Hefei 230031, China; 
2. Institute of Medicinal Plant Development, Beijing Union Medical College, 
Chinese Academy of Medical Sciences, Beijing 100193, China;
3. Anhui Science Institute for Drug Research Co. Ltd., Hefei 230088, China

Received:2012-08-30 Revised:2013-04-08 Online:2013-09-05 Published:2013-09-05
About author:*Corresponding author: Yu Shi-chun, Tel: 13956081725, E-mail：shichunyu@hotmail.com.
Supported by:
国家自然科学基金资助项目（81173511）；“十一五”“重大新药创制”国家科技重大专项——综合性新药研究开发技术大平台资助（2009ZX093012003）.

摘要/Abstract

摘要：

结合国内外文献，对唇形科风轮菜属植物近20年来的三萜皂苷与黄酮类成分的结构及波谱学研究内容进行综述. 目前已从风轮菜属植物中分离鉴定了42个三萜皂苷和23个黄酮. 总结了根据烯碳和羰基碳的NMR核磁数据特征推测三萜皂苷基本结构类型，依据含氧碳及相邻碳的化学位移值确定羟基的取代位置，依据三萜皂苷的碳谱数据鉴定皂苷中糖的种类和连接位置以及黄酮类成分特征性的核磁共振波谱规律. 对为进一步鉴定该属植物中三萜皂苷与黄酮类化合物结构以及进行波谱数据的归属具有重要的作用.

关键词: 风轮菜属, 结构类型, 皂苷类, 黄酮类, 波谱特征

Abstract:

This paper reviews domestic and international research progresses in studying the structures and NMR spectral features of triterpenoid saponins and flavonoids in Labiatae Clinopodium. So far, 42 saponins and 23 flavonoids have been isolated and identified. Base on the NMR data of alkene carbon and carbonyl carbon, the basic structures of triterpenoid saponins can be speculated. According to the chemical shifts of oxygenated carbon and the adjacent carbon, the hydroxyl substitution position can be determined. The type of sugar and connection location can be identified by the carbon spectral date of triterpenoid saponions. Meanwhile, the characteristic spectral features of flavonoids are summarized. NMR spectral characterization of triterpenoid saponins and flavonoids of the Clinopodium will facilitate further identification of new compounds from Clinopodium Linn.

Key words: Clinopodium, category, saponins, flavonoid, spectral features

中图分类号:

王圣男1，余世春1,3*，许旭东2，佘守军3，范石虎3. 风轮菜属三萜皂苷与黄酮研究进展及波谱特征[J]. 波谱学杂志.

WANG Sheng-nan1, YU Shi-chun1,3*, XU Xu-dong2, SHE Shou-jun3, FAN Shi-hu3. Triterpenoid Saponins and Flavonoids from Clinopodium Linn.: Chemical Component Analyses and NMR Spectral Features[J]. Chinese Journal of Magnetic Resonance.

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风轮菜属三萜皂苷与黄酮研究进展及波谱特征

Triterpenoid Saponins and Flavonoids from Clinopodium Linn.: Chemical Component Analyses and NMR Spectral Features

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