关键词: 雌激素, 肿瘤标志物, 磁共振多期动态增强成像, 宫颈癌, 联合诊断

Abstract:

Accurate and reliable diagnosis of cervical cancer is the key to clinical treatment and prognosis evaluation. In view of the low sensitivity of the existing serum estrogen and tumor markers to evaluate the features of the lesions, such as parauterine invasion and lymph node metastasis, a diagnostic method combined with multi-phase dynamic enhanced magnetic resonance imaging (DCE-MRI) was proposed in this paper. Firstly, serum estradiol (E2), follicle-stimulating hormone (FSH), luteinizing hormone (LH), glycochain antigen 125 (CA125), glycochain antigen 19-9 (CA19-9) and DCE-MRI were detected to analyze the correlation between cervical cancer stage and serum levels of E2, FSH, LH, CA125 and CA19-9. Then, cervical biopsy results were used as the gold standard to analyze the diagnostic accuracy of DCE-MRI for cervical deep muscle invasion and lymph node metastasis. Finally, the serum levels of E2, FSH, LH, CA125, CA19-9, DCE-MRI diagnosis and combined diagnosis of cervical cancer were analyzed based on receiver operating characteristic (ROC) curve. The experimental results showed that the AUC of combined diagnosis was 0.908, indicating that the combined diagnosis method could better distinguish benign and malignant cervical lesions, and the DCE-MRI parameters K^trans and K^ep further enriched the feature information, thereby improving the detection accuracy of lesions, and providing a new method for the differentiation of benign and malignant cervical cancer and its clinical staging.

Key words: estrogen, tumor markers, dynamic enhanced nuclear magnetic resonance, cervical cancer, joint diagnosis