大白鼠急性癫痫模型的DWI自身对照分析

波谱学杂志 ›› 1999, Vol. 16 ›› Issue (4): 344-349.

大白鼠急性癫痫模型的DWI自身对照分析

唐岳枫¹, 刘买利¹, 叶朝辉¹, 张先荣², 韩丹²

1. 中国科学院武汉物理与数学研究所波谱与原子分子物理国家重点实验室, 武汉 430071;
2. 湖北医科大学, 基础医学院, 生理教研室, 武汉 430071

收稿日期:1999-02-10 修回日期:1999-03-03 出版日期:1999-08-05 发布日期:2018-01-11
作者简介:唐岳枫,女,1975年出生,硕士研究生
基金资助:
国家自然科学基金(No:29872034)资助项目和中国科学院"九五"基础性重大项目(KJ951-B1-402)

SELF-COMPARISON OF BIEXPONENTIAL DIFFUSION OF WATER IN RAT BRAIN BEFORE AND AFTER PICROTOXIN INDUCED EPILEPSY

Tang Yuefeng¹, Liu Maili¹, Ye Chaohui¹, Zhang Xianrong², Han Dan²

1. State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, The Chinese Academy of Sciences, Wuhan 430071;
2. Department of Physiology, Hubei Medical University, Wuhan 430071

Received:1999-02-10 Revised:1999-03-03 Online:1999-08-05 Published:2018-01-11
Supported by:
This work is supported by grants from the Chinese Academy of Sciences(No:KJ 951-B1-402)and the National Natural Science Foundation of China (No:29872034)

摘要/Abstract

摘要： 用核磁共振成象方法研究了由印防已毒素(picrotoxin)诱发的大白鼠癫痫模型脑组织中水的双指数扩散现象.对模型诱发前后进行自身对照发现,在癫痫发作期间水扩散系数在全脑范围内特别在海马区和皮质区明显下降,同时快扩散部分的相对含量有所增加.本文根据核磁共振理论,对扩散系数的这种变化做了解释.此结果对于揭示癫痫发作的机制具有参考价值

关键词: 扩散加权成象, 水扩散系数, 大白鼠, 癫痫

Abstract: Biexponential diffusion of water in rat brain before and after picrotoxin induced epilepsy was reported for the first time based on MRI study at 4.7T. Self-comparision of the same rat (n=3) in the normal condition and after injection of picrotoxin shows that diffusion coefficients of both fast and slow diffusion components of water were reduced by 16.0% and 23.5%, respectively. Although the proton density was unchanged, the content ratio of the fast and slow diffused water was increased from 1.3:1 to 1.8:1 after the inducement of epilepsy. This may be the source of the increase in transverse relaxation time of water in the epilepsic rat brain.

Key words: MRI, Biexponential diffusion, Epilepsy

唐岳枫, 刘买利, 叶朝辉, 张先荣, 韩丹. 大白鼠急性癫痫模型的DWI自身对照分析[J]. 波谱学杂志, 1999, 16(4): 344-349.

Tang Yuefeng, Liu Maili, Ye Chaohui, Zhang Xianrong, Han Dan. SELF-COMPARISON OF BIEXPONENTIAL DIFFUSION OF WATER IN RAT BRAIN BEFORE AND AFTER PICROTOXIN INDUCED EPILEPSY[J]. Chinese Journal of Magnetic Resonance, 1999, 16(4): 344-349.

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